Product Description

The product C1s-C1INH Complex (CompTech#C1040) is made byinteracting purified protease inhibitor C1-INH (CompTech #A140) withpurified C1s enzyme (CompTech #A104) followed by purification. The protease inhibitor C1-INH prevents the spontaneous activation ofcomplement andlimits consumption of C2 and C4 by rapidly inactivatingC1r, C1s and MASP2. Itis the only plasma serine protease inhibitor(Serpin) capable of interactingwith and inhibiting activated C1.C1-INH interacts with the catalytic sites ofboth C1r and C1s. Theinteraction with activated C1r and C1s is covalentresulting incomplexes which are stable to SDS. C1s and C1r enzymes, however,areirreversibly inactivated by binding to C1-INH. C1s-C1INH (CompTech#C1040) isa very stable complex that remains intact even whensubjected to freeze/thawcycles with almost no loss of the complexform.

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IBEX Technologies是一家位于蒙特利尔的公司，通过其全资子公司IBEX Pharmaceuticals Inc生产和销售用于生物医学的试剂。

该公司的产品线包括用于体外诊断和研究的高纯度酶，以及用于骨关节炎研究的ELISA试剂盒。

IBEX还向体外诊断市场的主要参与者提供定制生产服务，包括定制发酵以及一次性诊断组件的灌装和冻干。