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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
ibexpharma/Heparinase I - Lyophilized NEW//60-010
产品编号:60-010
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$400.00
品      牌: ibexpharma
公      司:ibexpharma
公司分类:
ibexpharma/Heparinase I - Lyophilized NEW//60-010
商品介绍

Product Description

Rat C1q is purified from pooled normal rat serum. C1q is part of the C1 complex, which is thefirst complement component in the classical pathway of complement. The C1 complex is a non-covalent assembly ofthree different proteins (C1q, C1r, and C1s) bound together in acalcium-dependent complex. C1q has sixextended arms with domains at the end of each arm that bind to the Fc domainsof immunoglobulins such as IgG or IgM.When antibodies bind to antigens, forming immune complexes, they clusterallowing two or more of the six C1q arms to bind to the Fc domains ofantibodies. Rat IgG2 is very efficientwhen compared to IgG1 in activating complement (Medgyesi, G.A et., al., 1981).This is in contrast to the human system in which IgG1 activates complement butnot IgG2 (Redpath, S. et. al., 1998). Thebinding of multiple arms of C1q to immune complexes causes the two C1r proteinsin the complex (protease zymogens) to auto-activate. The activated C1r proteasescleave and activate the two C1s protease zymogens in the complex. The activated C1s cleaves complementcomponent C4 releasing C4a and initiating covalent attachment of C4b to theactivating surface. Activated C1s alsocleaves C2 and the larger fragment of C2 binds to the surface-attached C4bforming C4b,C2a, the C3/C5 convertase of the classical pathway.

Rat IgG1 cannot activate complement whereas rat IgG2 does.

(For full product description see link...)

品牌介绍

IBEX Technologies是一家位于蒙特利尔的公司,通过其全资子公司IBEX Pharmaceuticals Inc生产和销售用于生物医学的试剂。

该公司的产品线包括用于体外诊断和研究的高纯度酶,以及用于骨关节炎研究的ELISA试剂盒。

IBEX还向体外诊断市场的主要参与者提供定制生产服务,包括定制发酵以及一次性诊断组件的灌装和冻干。


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